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OCR: (F) was the Although CRH (initially referred to as C first of the hypophysiotrophic factors to me recognised and to be given the generic n 955), its 'releasing factor' (by Saffran and Schally, til 1981 by chemical nature was not determined ur Vale and collaborators. Fig. 1.22). increased Patients injected with CRH respond wit ACTH and plasma corticosteroid levels nd In addition, the peptides B-lipotrophin a hesised in endorphin are stimulated; these are syn s part of the corticotrophs, together with ACTH, the precursor molecule POMC (pro-opiomelanocortin).